The expression avoir beau+infinitive can usually be translated by although or however.
Il a beau être aisé, il n’est pas heureux. Although he has a lot of money, he is not happy.
Il a beau dormir, il est toujours fatigué. However much he sleeps, he is always tired
Il avait beau habiter au bord de la mer,il n’a jamais appris à nager. Although he lived by the sea, he never learned how to swim.
Elle aura beau essayer, ce sera inutile.. However much she tries, it will be useless.